Publications scientifiques
IMMUNOLOGIE et IMMUNOCHIMIE
55 publications dont :
GEFFARD M. R., PUIZILLOUT J.J., DELAAGE M.A. A single radioimmunological assay for serotonin, N-acetylserotonin, 5-methoxytryptamine, and melatonin. J. of Neuroch., (1982) 39, 1271-1277.
GEFFARD M., BUIJS R.M., SEGUELA P., POOL C.W. and LE MOAL M. First demonstration of highly specific and sensitive antibodies against dopamine. Brain Res., (1984) 294, 161-165.
SEGUELA P., GEFFARD M., BUIJS R.M. and LE MOAL M. Antibodies against g-aminobutyric acid : Specificity studies and immunocytohemical results. Proc. Natl. Acad. Sc. USA, (1984) 81, 3888-3892.
GEFFARD M., Mc RAE-DEGUEURCE A. and SOUAN M.L. Immunocytochemical detection of acetylcholine in the rat central nervous system. Science, (1985) 229, 77-79.
GEFFARD M., TOURET M. and KITAHAMA K. First characterization of 5-hydroxytryptophan in rat brain by using specific antibodies, Brain Res., (1987), 426, 191-196.
LOIRAND G., FAIDERBE S., BARON A., GEFFARD M. and MIRONNEAU J. Autoanti-phosphatidylinositide antibodies specifically inhibit noradrenaline effects on Ca2+ and Cl- channels in rat portal vein myocytes. J. Biol. Chem., (1992) 267, 4312-4316.
BESSEDE A., GARGARO M., PALLOTTA T., MATINO D., SERVILLO G., BRUNACCI C., BICCIATO S., MAZZA E., MACCHIARULO A., VACCA C., IANNITTI R., TISSI L., VOLPI C., BELLADONNA M., ORABONA C., BIANCHI R., LANZ T., PLATTEN M., A DELLA FAZIA M., PIOBBICO D., TERESA ZELANTE T. , FUNAKOSHI H., NAKAMURA T., GILOT D., DENISON M., J GUILLEMIN G., DUHADAWAY J., PRENDERGAST G., METZ R., GEFFARD M., BOON L., ROMANI L., VEYRET B., GROHMANN U., FALLARINO F. and PUCCETTI P.,Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature (2014), 511, 184-190.
NEUROBIOLOGIE
176 publications dont :
BUIJS R.M., GEFFARD M., POOL C.W. and HOORNEMAN E.M.D. The dopaminergic innervation of the supraotic and paraventricular nucleus. A light and electron microscopical study. Brain Res. (1984), 323, 65-72.
Mc RAE-DEGUEURCE A. and GEFFARD M. One perfusion mixture for immunocytochemical detection of noradrenaline, dopamine, serotonin and acetylcholine in the same rat brain. Brain Res., (1986) 376, 217-219.
KITAHAMA K., MONS N., OKAMURA M., JOUVET M. and GEFFARD M. Endogenous L-DOPA, its immunoreactivity in neurons of midbrain and its projection fields in the cat. Neurosci. Letters, (1988), 95, 47-52.
VUVAN T., GEFFARD M, DENIS P., SIMON A., and N’GUYEN-LEGROS J. Radioimmunoligand characterization and immunohistochemical localization of dopamine D2 receptors on rads in the rat retina. Brain Res., (1993), 614, 57-64.
COVENAS R., MANGAS A., BODET D., DULEU S., MARCOS P. and GEFFARD M. Vitamin C in the monkey brain. In vitamin C : nutrition, side effects and supplements. Jackson, Ch. M.(ed.), Nova Science Publishers, New York (2011) 275-288.
MANGAS A., BODET D., DULEU S., YAJEYA J., GEFFARD M. and COVENAS R., Direct visualization of retinoic acid in the rat hypothalamus : an immunohystochemical study. Neurosc. Letters, (2012) 509, 64-68.
COVENAS R., GONZALEZ-FUENTES J., RIVAS-INFANTE E., LAGARTOS-DONATE M.J., MANGAS A., GEFFARD M., ARROYO-JIMENEZ M.M., CEBADA-SANCHEZ S., INSAUSTI R., MARCOS P., Developmental study of vitamin C distribution in children’s brainstems by immunohistochemistry. Annals of Anatomy (2015), 201, 65-78.
MANGAS A., YAJEYA J., GONZALEZ N., DULEU S., GEFFARD M., COVENAS R., NO-tryptophan : a new small molecule located in the mammalian brain, European Journal of Histochemistry (2016) 60:2692, 199-202
MANGAS A., YAJEYA J., GONZALEZ N., HUSSON M., GEFFARD M., COVENAS R., Detection of pantothenic acid-immunoreactive neurons in the rat lateral septal nucleus by a newly developed antibody. Folia histochemica et cytobiologica (2016) 54, 186-192.
COVENAS R., MANGAS A., SANCHEZ M.L., CADENA D., HUSSON M. and GEFFARD M. , Generation of specific antisera directed against D-amino acids: focus on the neuroanatomical distribution of D-glutamate and other D-amino acids. Folia Histochem Cytobiol (2017) 55,177-189, doi : 10.5603/FHC.a2017.0023.
SCLEROSE EN PLAQUES
27 publications dont :
BOULLERNE A., PETRY K.G., MEYNARD M. and GEFFARD M. Indirect evidence for NO involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine. J. of Neuroimmunol., (1995), 60, 117-124.
BOULLERNE A. I., PETRY K.G. and GEFFARD M. Circulating antibodies directed against conjugated fatty acids in sera of patients with Mutiple Sclerosis. J. of Neuroimmunol., (1996), 65, 75-81.
GEFFARD M., TRANCHANT C., FLEURY M.C., WIERTLEWSKI S., GUENNOC A.M. and DABADIE M.P. GEMSEP1 : a new drug candidate for secondary progressive form of Multiple Sclerosis. 21th Congress ECTRIMS. 28 September – 01 October 2005, Thessaloniki (Greece).
MANGAS A., COVENAS R., BODET D., DULEU S. and GEFFARD M., A new drug candidate (GEMSP) for multiple sclerosis. Current Medicinal Chemistry (2009) 16, 3203-3214.
GEFFARD M., DE BISSCHOP L., DULEU S., POUNS O., FERRAN G., BESSEDE A., HASSAINE N., AUTRAN J.-L., BODET D., MANGAS A., and COVENAS R., Endotherapia. Anti-inflammatory and anti-allergy agents in Medicinal Chemistry, Spécial Issue, Betham ed. Michigan (2010) 9, N°3. 197-211(15).
GEFFARD M., DULEU S., BESSEDE A., COVENAS R., MANGAS A., A new paradigm for multiple sclerosis. In Multiple sclerosis. A new paradigm. Editor : GEFFARD M., Nova Science Publishers, (2011) pp 153-184.
GEFFARD M., MANGAS A., COVENAS R., Follow up of Multiple Sclerosis patients treated with Endotherapia (GEMSP), Biomedical Reports, (2017) p 307-313 DOI : 10.3892/br.2017.857.
TABERA S., MANGAS A., GEFFARD M., COVENAS R., Immunomodulatory effects of mesenchymal stem cells on T-and B-cells in a quiescent state in a chronic experimental model of autoimmune encephalomyelitis. Neuro Open J (2017) doi. org/10.17140/NOJ-4-128, 38-49
SCLEROSE LATERALE AMYOTROPHIQUE
6 publications dont :
NICAISE C., COUPIER J., DABADIE M.P., DE DECKER R., MANGAS A., BODET D., PONCELET L., GEFFARD M. and POCHET R. Gemals, a new drug candidate, extends lifespan and improves muscular performance in an amyotrophic lateral sclerosis rat model. Amyotrophic Lateral Sclerosis and other motor neuron disorders (2008) 9(2), 85-90.
GEFFARD M., MANGAS A., BEDAT D., COVENAS R., GEMALS : A Promising Therapy for Amyotrophic Lateral Sclerosis. Experimental and Therapeutic Medecine (2018) 15, 3203-3210.
MYASTHENIES
6 publications dont :
SOUAN M.L. and GEFFARD M. Immunological similarities between an experimental autoimmune myasthenia gravis model and human myasthenia gravis. Neurosc.Letters, (1986), 68, 282-287.
GEFFARD M. and SOUAN M.L. Experimental autoimmune Myasthenia Gravis and Myasthenia Gravis : comparison of the immunological results obtained. In Myasthenia Gravis : biology and treatment. Annals of the N.Y. Academy of Sciences, (1987), 505, 712-714.
ANTICORPS ET CANCERS
20 publications dont :
FAIDERBE S., CHAGNAUD J.L., CHARRIER M.C., PEYRON M.A., WAFFLART J. and GEFFARD M. Auto antibodies directed against lipid membrane components in sera of patients with malignant tumors. Cancer Detection and Prevention, (1991), 15, 199-203.
CHAGNAUD J.L., BOUREME D., FAIDERBE S. and GEFFARD M. Visualization of a protein involved in seric immune complexes of patients with epithelial tumors having elevated levels of anti-benzo(a)pyrene-like IgA. Cancer Letters, (1991), 60, 229-235.
CHAGNAUD J.L., FAIDERBE S. and GEFFARD M. Identification and immunochemical characterization of IgA in sera of patients with mammary tumors. Int. J. of Cancer, (1992), 50, 395-401.
FAIDERBE S., CHAGNAUD J.L. and GEFFARD M. Identification and characterization of a specific auto anti phosphatidylinositol immune response during the time course of benzo(a)pyrene – induced malignant tumors in female Sprague-Dawley rats. Cancer Res., (1992), 52, 2862-2865.
CHAGNAUD J.L., FAIDERBE S. and GEFFARD M. Curative effects on rat sarcomas obtained after a treatment combining two monoclonal antibodies. Anti-Cancer Drugs, (1994), 5, 361-366.
POUNS O., MANGAS A., COVENAS R. and GEFFARD M. Circulating antibodies directed against “polycyclic aromatic hydrocarbon-like” structures in the sera of cancer patients. Cancer Epidemiology. (2009) 33, 3-8.
ACCIDENT VASCULAIRE CEREBRAL
4 publications dont :
MANGAS A, YAJEYA J, GONZALEZ N, RUIZ I, GEFFARD M, COVENAS R. 3-hydroxi-anthranilic acid is early expressed in stroke. Eur J Histochem 2016; 60:2709. doi:10.4081/ejh.2016.2709
MANGAS A, YAJEYA J, GONZALEZ N, RUIZ I, PERNIA M, GEFFARD M, COVENAS R. Gemst : a tailor-made combination that reverts neuroanatomical changes in stroke. Eur J Histochem 2017; 61:2790. doi:10.4081/ejh.2017.2790
MANGAS A, HEREDIA M, RIOLOBOS A, de la FUENTE A, CRIADO JM, YAJEYA J, GEFFARD M, COVENAS R. Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury European Journal of Histochemistry (2018), 62 : 2985, 278-284
AUTRES PATHOLOGIES
40 publications dont :
AMARA A., CONSTANS J., CHAUGIER C., SEBBAN A., DUBOURG L., PEUCHANT E., PELLEGRIN J.L., LENG B., CONRI C. and GEFFARD M. Autoantibodies to malondialdehyde-modified epitope in connective tissue diseases and vasculitides. Clinical and Exp. Immunol., 1995, 101, 1-6.
OKOMO-ASSOUMO M.C., GEFFARD M., DAULOUEDE S., CHAUGIER C., LEMESTRE L.-L. and VINCENDEAU P. Circulating antibodies directed against tryptophan-like epitopes in sera of patients with human African trypanosomiasis. Am J. Trop. Med. Hyg., (1995), 52, 461-467.
SEMBALLA S., OKOMO-ASSOUMOU M.C., BUSCHER P., LEMESRE JL., MAGEZ S., DAULOUEDE S., HOZMULLER P., GEFFARD M. and VINCENDEAU P. Identification of a tryptophan-like epitope borne by the variable surface glycoprotein (VSG) of African trypanosomes. Experimental Parasitology (2007) 115(2), 173-180.
BARICHELLO T., DAGOSTIM SAVI G., PANATTO A.P., GENEROSO J.S., CIPRIANO A.L., REZIN G.T., DAL-PIZZOL F., STRECK E.L., PETRONILHO F., VIDAL L. and GEFFARD M., Effect of New Compound with Antioxidant Potential in the Energy Metabolism of Adults Rats after Pneumococcal Meningitis. American Journal of Pharmacology and Toxicology (2012) 7(2) 49-61.
MAES M., KUBERA M., LEUNIS J.C., BERK M., GEFFARD M., BOSMANS E., In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes. Acta Psychiatrica Scandinavica (2013) 127(5), 344-354.
VIDAL L., THUAULT V., MANGAS A., COVENAS R., THIENPONT A., and GEFFARD M., Lauryl-Poly-L-Lysine : a new antimicrobial agent. Journal of Amino Acids. (2014), 2014, 1-10.
KANCHANATAWAN B, THIKA S, SIRIVICHAYAKUL S, CARVALHO A, GEFFARD M, MAES M, In schizophrenia, Depression, Anxiety, and Physiosomatic Symptoms are strongly related to Psychotic symptoms and excitation, impairments in episodic memory , and increased production of neurotoxic tryptophan catabolites : a multivariate and machine learning study. Neurotoxicity research. (2018) DOI. org/10.1007/s12640-018-9868-4
KANCHANATAWAN B, SRISWASDI S, THIKA S, SIRIVICHAYAKUL S, CARVALHO A, GEFFARD M, KUBERA M, MAES M., Deficit schizophrenia is a discrete diagnostic category defined by neuro-immune and neurocognitive features: results of supervised machine learning. Metab Brain Dis. (2018) DOI. org/10.1007/s11011-018-0208-4